DOI: 10.33917/mic-5.124.2025.57-68

Boron-neutron capture therapy (BNCT) is one of the most effective treatments for a number of oncological diseases. Boron isotope 5¹⁰B is injected into malignant tumors and then it is irradiated with thermal neutrons. The decay products of boron (lithium and helium nuclei) have a low mileage in body tissue and destroy the tumor cells. Compact neutron generators (as neutron sources based on proton or deuton accelerators) are attracting more and more attention. Interaction of proton or deuton with a cooled target made of special materials generates neutrons. In the world there are more than sixteen BNCT centers based on compact accelerators at various stages of development. Russia has accumulated extensive experience in the production of compact neutron generators for various industries, however, their use for nuclear medicine purposes is just beginning. Therefore, the economic analysis of the creation of BNRT centers is of great scientific and practical interest. In this paper, an attempt is made to evaluate the effectiveness of investments into BNCT-centr and the cost of medical services using neutron generators, based on the methodology developed at the National Research Nuclear University MEPhI. Published information on the capital and operating costs of a number of foreign medical centers was used as initial data for the investment analysis of BNCT-centers. It is shown, as the result of the calculations, that depending on the amount of financial costs for BNCT-centr construction and operation and on the number of patients served, the cost of medical services may exceed 10-20 thousands of dollars per patient.

References:

1. Public report 2023. Rosatom. 172 p. URL: https://report.rosatom.ru/go/rosatom/go_rosatom_2023/app/rosatom_2023_1.pdf

2. Bichkurina M.I., Kasatov D.A., Kolesnikov Y.A. et al. Boron-neutron capture therapy: physical aspects. Oncological Journal: radiation diagnostics, radiation therapy. 2024;7(4):75-83.

3. Advances in Boron Neutron Capture Therapy. IAEA, Vienna, 2023. 416 p.

4. Kumada H., Takeji Sakae & Hideyuki Sakurai. Current development status of accelerator-based neutron source for boron neutron capture therapy. EPJ Techniques and Instrumentation. 2023;10(18):2-15.

5. Lipengolts А.А., Grigorieva Е.Yu., Ivanov S.M. et al. Current Status of Clinical Neutron Capture Therapy. Oncological Journal. 2018;1(1):15-18.

6. Chernukha A.E., Saburov V.O., Adarova A.I. et al. Three-dimensional models and complimentary geometry for dose evaluation in NG-24MT-based neutron. Izvestiya Vuzov. Yadernaya Energetika. 2022;3:158-167.

7. Golubev S.V., Izotov I.V., Razin S.V. et al. Compact neutron source for boron neutron capture therapy. Izvestya Vuzov. Radiofizika. 2016;59(8/9):760 -768.

8. Koryakin S.N., Kaydan N.A., Isaeva E.V. et al. Experience in using a portable domestic neutron generator in the schemes of gamma neutron therapy of pets with malignant neoplasms. Radiation and risk. 2018;27(1):94-106.

9. Ivanov A.A., Smirnov A.N., Taskaev S.Yu. et al. Accelerator neutron source for boron neutron capture therapy. Achievements of physical sciences. 2022;192(8):893-912.

DOI: 10.33917/mic-5.124.2025.13-20

The method of analytical calculation of the microeconomic criteria of investment efficiency into PWR Small Modular Reactor is presented as depending on the engineering, physical and economic parameters of the reactor. This method is convenient for multi-variant preliminary searches of acceptable criteria for SMR competitiveness. As a prototype SMR reactor is being considered RITM-200N with a period of 6 years of continuous work (before fuel overload) and the use of tolerant fuels, accident-resistant, consisting of metal ceramic composition in a chromium-nickel alloy shell (42XHM). The results of calculations of the relationship between engineering and physical parameters of the reactor, electricity costs and the payback period for investments are given.

References:

[1-19] see in No. 4 (123)/2025. p. 67-69

20. Petrunin V.V. Reactors for small nuclear power plants. Vestnik RAS. 2021;91(6):528-540.

21. Petrunin V.V. et al. Scientific and technical aspects of reactor RITM-200N creation for small nuclear power plants. Atomic Energy. 2023;134(1-2):3-10. URL: https://www.j-atomicenergy.ru/index.php/ae/article/view/5265

22. Semenov E. V., Kharitonov V.V. Analytical Construction of Grid Diagrams for Burnup of Nuclear Fuel of Different Compositions in Water-Cooled Reactors. VANT, Ser. Physics of nuclear reactors. 2024;1: 51-57.

23. Semenov E. V., Kharitonov V.V. Analytical Dependence of the Burnup on the Enrichment of Prospective Fuel and the Parameters of the Fuel Campaign of Reactors/ Izvestiya vuzov. Yadernaya Energetika. 2023;3:94-105

24. Future of Nuclear Power. An Interdisciplinary MIT Study. Massachusetts Institute of Technology, 2003. 180 р. URL: https://web.mit.edu/nuclearpower/pdf/nuclearpower-full.pdf

25. Nuclear New Build: Insights into Financing and Project Management. NEA No. 7195. OECD 2015. 248 р. URL: https://oecd-nea.org/upload/docs/application/pdf/2019-12/7195-nn-build-2015.pdf

26. JSC Atomenergoprom. Annual Report, 2024. 235 p. URL: https://atomenergoprom.ru/upload/iblock/9de/

DOI: 10.33917/mic-4.123.2025.62-69

The method of analytical calculation of the microeconomic criteria of investment efficiency into PWR Small Modular Reactor is presented as depending on the engineering, physical and economic parameters of the reactor. This method is convenient for multi-variant preliminary searches of acceptable criteria for SMR competitiveness. As a prototype SMR reactor is being considered RITM-200N with a period of 6 years of continuous work (before fuel overload) and the use of tolerant fuels, accident-resistant, consisting of metal ceramic composition in a chromium-nickel alloy shell (42XHM). The results of calculations of the relationship between engineering and physical parameters of the reactor, electricity costs and the payback period for investments are given.

References: 

1. The white book of nuclear energy. A closed NFC with fast reactors / Edited by prof. Е.О. Adamov. М.: Publishing house АО «NIKIET», 2020. 502 p.

2. Alekseev P.N. et al. Two-component nuclear power system with thermal and fast reactors in a closed nuclear fuel cycle / Edited by N.N. Ponomarev-Stepnjy. М.: Tekhnosfera, 2016.160 p.

3. Energy, Electricity and Nuclear Power Estimates for the Period up to 2050. 2024 Edition. IAEA-RDS-1/44 ISBN 978-92-0-123424-7. 148 p.

4.  Abramova A.V., Kharitonov V.V. Analytical modeling of scenarios for the sustainable development of global two-component nuclear energy. Part 1. Scenarios with thermal reactors.Atomic energy, 2024;137(3-4)131-137.

5. The Path to a New Era for Nuclear Energy/ International Energy Agency (IEA). 2025. 99 p.

6. Small modular reactors: challenges and opportunities. NEA No. 7560, 2021. 56 p.

7. Advances in Small Modular Reactor Technology Developments. A Supplement to: IAEA Advanced Reactors Information System (ARIS). 2020 Edition. IAEA, September 2020. 354 p.

8. Semenov E. V., Kharitonov V.V. Microeconomics of improving the safety of nuclear power plants based on using of accident tolerant fuel. Microeconomics. 2021;5(100):49-62.

9. Semenov E. V., Kharitonov V.V. Analytical dependence of the burnup on the enrichment of prospective fuel and the parameters of the fuel campaign of reactors. Atomic energy. 2023;135(1-2):77-83.

10. Low nuclear power station: a new direction of energy development. V. 2 / Edited by RAS academician А. А. Sarkisov. М.: Akadem-Print, 2015. 387 p.

11. Dragunov Yu. G. et al. Approaches to development of SMR based on a gas-cooled reactor. Atomic Energy. 2019;126(5):243-248.

12. Kudinov V.V. В. Low-power nuclear power plants in NIKIET. «Small nuclear power industry: Yesterday, Today, Tomorrow (Retrospective and Prospects)». NIKIET, ROSATOM, 2022.  https://nsrus.ru/files/ks131022/

13.Smirnova L.S., Korolev S.A. Factor analysis for integrated approach to economic of Small nuclear power plant projects. Atomic energy. 2024;137(1-2):3-14.

14. World Nuclear Association. Small Nuclear Power Reactors. Small Nuclear Power Reactors – World Nuclear Association. URL:  world-nuclear.org

DOI: 10.33917/mic-6.119.2024.104-120

In this study, the causes of unsatisfactory organization of accessible and high-quality medical care were diagnosed, directions for improving its organization were determined, and an attempt was made to economically evaluate the role of industry executives in the efficiency of using budget funds allocated for the development of health care.

The proposed approach enables the development of scientifically based risk minimization tools and mechanisms to achieve the goals of improving the organization of highly qualified, accessible and high-quality medical care.

References:

1. Cipolla C. The 5 basic laws of human stupidity, according to Cipolla. News Editors. Book. 11/05/2021. URL: https://www.naturalnews.com/

2. Cipolla C.M.  The Basic Laws of Human Stupidity. 2024. URL: https://thebeerthrillers.com/2023/11/20/

3. Ганнушкин П.Б. Клиника психопатий их статика, динамика, систематика. Москва. Издательство Юрайт. 2023. 165 c.

4. Voskanyan Y., Kidalov F., Shikina I., Kurdyukov S., Andreeva O. Model of Individual Human Behavior in Health Care Safety Management System. In: Antipova T. (ed.). Russian Sklifosovsky Journal of Emergency Medical Care. 2022. № 11(2). p. 30.

5. Gill S., Mills P.D., Watts B.V., Paull D.E., Tomolo A. A Review of Adverse Event Reports from Emergency Departments in the Veterans Health Administration. J Patient Saf. 2021;17(8):898–903.

6. Panagioti M., Khan K., Keers R.N., Abuzour A., Phipps D., Kontopantelis E., et al. Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ. 2019;366:l4185.

7. Lavrenteva M. V. Is healthcare a public good or a market service? A critical analysis of the discussion of strategies and tactics for the development of the global healthcare system in post-Covid conditions based on the current debates around the works of B. Gates and the World Health Organization. 2023;7(133).

8. Zadvornaya O.L. Conceptual approaches to improving the qualifications of personnel for the implementation of lean manufacturing technologies in medical organizations providing primary health care. Medical technologies. Assessment and selection. 2020;1: 48–54.

9. Omelyanovsky V.V., Gorkavenko F.V., Ignatyeva N.V., Mukhortova P.A., Ryzhova O.R., Teptsova T.S., Kingshott A.A., Kondratieva B.B. Real clinical practice: principles of use in making management decisions and assessing healthcare technologies. Pharmacoeconomics. Modern pharmacoeconomics and pharmacoepidemiology. 2023;16(2):283–290.

10. Voskanyan Yu.E. Adverse Events Associated with the Provision of Health Care, or the Downside of Healthcare in Foreign Countries (a Systematic Review). Surgery. Pirogov Journal. 2022;4:79–98.

11. Vetoshkin S. Digitalization Has Turned Medicine into a «Mouse Fray». Report at a Meeting of the Expert Council on Modern Management and Digitalization in Healthcare of the Duma Committee on Health Protection. 06/21/2024. URL: https://svpressa.ru/blogs/article/420598/